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Chunk #16 — Developmental roles of SWI/SNF complexes — Developmentally distinct BAF complexes in mammalian development

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Chromatin remodelling during development.
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(also known as BAF180)) are expressed in the epicardium and have roles that are non-redundant with those of BAF60C in mediating coronary development and cardiac chamber maturation43,44. By contrast, PBAF complexes are not required for ESC formation or function: deletion of the signature subunit of these complexes, polybromo (BAF180), does not impair the formation of the inner cell mass or the production of different germ layers43.