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Chunk #24 — DISCUSSION

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A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.
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We have used a GWAS strategy in a search for genes involved in AD, ND and comorbid AD/ND in samples from Australia and the Netherlands. Within the Australian data set, there were four genome-wide significant results (p<5×10−8): a SNP in ARHGAP10 for ND; and SNPs in KIAA1409 and near MARK1 and DDX6 for the comorbid analyses. There were no significant associations for AD alone.