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Chunk #43 — Discussion — Overall conclusions and further work

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The association between depressive symptoms from early to late adolescence and later use and harmful use of alcohol.
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substance use [44]. The finding that the nature of the alcohol outcome may be critical in determining whether an association with depressive symptoms exists is an important one, and should be considered when comparing the results of studies that examine the relationships between depressive symptoms and alcohol use. The psychological and/or biological mechanisms underlying these associations should be the focus of additional research.