EtOH has consistent inhibitory actions on iGluRs (although see Lu and Yeh 1999) (Fig. 1c, d). Inhibition of NMDARs at EtOH concentrations associated with intoxication is the best characterized of these effects (Criswell et al. 2003; Dildy and Leslie 1989; Hoffman et al. 1989; Lima-Landman and Albuquerque 1989; Lovinger et al. 1989). The synaptic responses mediated by NMDARs are also reduced by EtOH (Lovinger et al. 1990; Morrisett and Swartzwelder 1993; Roberto et al. 2004b; Wang et al. 2007).
