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Chunk #19 — Results — Shared genetic effects between cis-eQTLs and central nervous system traits

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Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases.
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10-08EXSCZGATAD2Ars12975119-0.12 (0.02)1.34 x 10-08MSRGS1rs3011685-0.47 (0.08)1.54 x 10-08SCZKMT2Ers356011450.29 (0.05)1.64 x 10-08MSIFITM1rs64219830.49 (0.09)1.78 x 10-08MICSCZZNF823rs729866300.19 (0.03)4.14 x 10-08MSIFITM3rs34481144-0.30 (0.05)2.34 x 10-08SCZPTPRUrs267700-0.19 (0.03)4.28 x 10-08EXMSTBX6rs38096270.20 (0.04)3.25 x 10-08SCZRERErs3017920.16 (0.03)4.99 x 10-08MSABCB9rs17901160.47 (0.09)3.55 x 10-08SCZGLYCTKrs64453580.19 (0.04)7.22 x 10-08MSTYMPrs131795-0.25 (0.05)6.20 x 10-08SCZATP13A1rs72456720.30 (0.06)1.08 x 10-07MSSCO2rs1317940.33 (0.06)6.20 x 10-08SCZCLCN3rs726966570.24 (0.05)1.14 x 10-07Harmonized eQTL and GWAS SNP effects and single-SNP Wald ratio-effect (WR) estimates are reported for all genes with Wald ratio effects at P < 1.865 × 10−7. Brain-trait outcomes have been abbreviated as follows: BD, bipolar disorder; MDD, major depressive disorder (broad depression category); FTD, frontotemporal dementia; JME, juvenile myoclonic epilepsy. The cell types (CT) with which the eQTL significantly interacts (BH-FDR < 0.05) are abbreviated as follows: AST, astrocytes; EX, excitatory neurons; MIC, microglia; NEU, other neuron; and OLI, oligodendrocytes. This table is a subset of Supplementary Table 12.