As in our previous study, the connection between the PCC and the affected HC predicted better verbal and visuospatial memory capacity (McCormick et al., 2013a). Here, we extend this finding with a larger cohort of patients and refined composite memory scores rather than the single memory tests we used previously (see Fig. S2). Of note, patients in the earlier study are a subset of the current study cohort. Comparable to the previous findings, in patients with left mTLE, connectivity from the PCC to the left HC (PCC–lHC) correlated with verbal memory scores (r2 = 0.30, p = 0.001) and in patients with right mTLE, connectivity from the PCC to the right HC (PCC–rHC) correlated with visuospatial memory scores (r2 = 0.18, p = 0.015). However, brain scores reflecting the functional integrity of the entire DMN predicted verbal and visuospatial memory capacity more accurately than PCC–HC connectivity alone (see Fig. 3). In patients with left mTLE, DMN connectivity correlated with verbal memory scores (r2 = 0.61, p < 0.001) and in patients with right mTLE, DMN connectivity correlated with visuospatial memory
