blood pressure, and aortic root size. Interestingly, inflammatory bowel disease and ulcerative colitis variants show enrichment in both immune and gastrointestinal enhancer marks, suggesting dysregulation of both organs may underlie disease predisposition. Both attention deficit hyperactivity disorder and adiponectin levels were enriched in brain regions, consistent with causal roles in brain dysregulation86-87. In contrast, late-onset Alzheimer's disease variants were enriched in immune cell enhancers, rather than brain, consistent with recent evidence of a possible immune and inflammatory basis88-90.
