In addition to SNPs in two of the most promising SCZ candidate genes, we replicated several recently identified susceptibility genes for SCZ in an independent family-based replication sample. Our family-based replication also suggests that previous claims implicating the MHC region as a susceptibility region for SCZ cannot be discarded as population stratification artifacts. Pathway analyses of the many small effects reveal several biological themes involved in brain function, immune response, and biological functions of potential importance for the development of SCZ. The present investigation is, to our knowledge, the first family-based replication that confirms several of the recent mega- and meta-analyses top findings in a completely independent study sample using a different genotyping assay than what was used in the initial detection.
