Given the poor overlap between the five data sets (Table 1), their integration allows a more complete coverage of the real interactions for each human protein. For example, the protein TP53 has a total of 408 interactions in NCG, 237 of which derive from HPRD, 214 from BioGRID, 159 from IntAct, 122 from MINT and 38 from DIP. The primary interaction network for each cancer protein is visualized using Medusa (38) and all interactors are provided with information on their duplicability, orthology, evolutionary appearance and possible involvement in cancer.
