below (Equation 1). Count scores were calculated with β = 1 and weighted scores with β = effect size of each risk allele (A) reported by Speliotes et al.[9] summed over the number of risk alleles in the score (n). To determine if there was significant effect size differences by GRSS methodology z-scores were computed in R using Equation 2 and p-values assigned based on the standard normal distribution.12
