Results from GREML analyses showed that common SNPs significantly captured a substantial part of the heritability of MDD (estimate=0.31; se=0.13; p=0.006). We estimated also h2SNP for the subtypes defined by appetite/weight symptoms since they allowed us to include a higher number of cases (587 decreased, 385 increased) as compared to LCA-subtypes (228 typical, 251 atypical). With the available sample size, for both subtypes 80% power to detect a significant (>0) h2SNP could be reached only assuming heritability estimates higher than those for MDD (eFigure 3). Estimates of h2SNP were significant for both decreased (K=0.072; estimate=0.38; se=0.17; p=0.01) and increased (K=0.047; estimate=0.43; se=0.20; p=0.01) appetite/weight, and higher than those for MDD, although with large standard errors due to restricted sample sizes.
