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Chunk #26 — Discussion

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Network analysis of intrinsic functional brain connectivity in Alzheimer's disease.
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Table 2 provides a comparison of results obtained from our study to all of the above-mentioned results on the small-world characterization of functional brain networks. Our results are largely comparable to small-world metrics reported by Salvador et al. also using task-free fMRI in healthy human subjects [24],[37]. The small-world metrics reported by Stam et al. analyzing beta-band EEG in controls and AD subjects are also largely consistent with our results [25]. It is interesting to note that whereas we report similar characteristic path lengths but different cluster coefficients between AD and controls, the EEG study found the converse (characteristic path lengths differed between AD subjects and controls but cluster coefficients did not). We believe that this discrepancy may be related to significant volume conduction in scalp EEG data [38] which may reduce sensitivity to detect differences in short-range connectivity while enhancing the relative sensitivity to detect differences in long-range connectivity. Other methodological differences may also contribute–the use of synchronization likelihood as their association measure, which unlike wavelet correlation is sensitive to non-linear coupling. Also, the poor spatial resolution of scalp