Factor analysis of the 14–20 outcomes per sample overall identified five factors with Eigenvalues above 1 and explained variance >10%, of which two appeared to be made up by similar variables in multiple cohorts (see Table S3). The latent factor lifetime substance use was present in 25Up and S4S and was not significantly associated with CADM2. A tobacco (ab)use factor could be discerned in all datasets but was only significantly associated with CADM2 in UKB with p = 8.45e‐06. In UKB there were two other factors, one for lifetime smoking and one for regular alcohol use, which were both associated with CADM2 (p = 1.01e‐22 and p = 5.84e‐13, respectively). Finally, in NTR there was a self‐control factor that was associated with CADM2 (p = 2.28e‐08).
