Chunk #12 — Materials and Methods — PRS construction — SNP selection.

Source

Generalizing polygenic risk scores from Europeans to Hispanics/Latinos.

Embedded

yes

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In simulation studies, which focused on the effects of LD and sample sizes, we selected only a single lead SNP from the region based on the same criteria described above (lead EA, lead in META, etc.), without setting a p-value threshold or clumping.