In an effort to understand the attitudes of AAs on return of results from ES/WGS and ultimately empower them to make more informed decisions about whether to undergo ES/WGS and how to manage their results, we performed a qualitative analysis of data obtained from a series of focus groups conducted as part of a larger, ongoing effort to develop innovative and improved strategies and tools for return of results from ES/WGS. The specific questions that we address include: (1) What do AA participants think are the risks and benefits of WGS and why?; (2) What do AA participants think about receiving WGS results for themselves and for their children?; (3) How do AA participants make decisions about whether to receive WGS results, and what to do with them?; and (4) How do AA participants perspectives on WGS differ from those of non-AAs?