distinction from the controls was seen with respect to those items related to dependence symptoms (items 4-6) and alcohol-related problems (items 7-10). For these seven items, the mean response was ≤0.5 and ≥2.2 for controls and problem/ treated groups, respectively, which on a 'occurs on a monthly or more' basis represents an affirmative response by ≤ 2 per cent and ≥ 63 per cent of the respective group subjects.