In an attempt to identify functionality in non-coding regions at the three loci, we utilized FunciSNP version 0.9910, which systematically integrates the 1,000 Genomes SNP data (1KGP, April 2012) with chromatin features of interest. In order to capture regulatory elements, we used 73 different chromatin features generated by next-generation sequencing technologies in brain and adipose tissues from the NIH Epigenomics Roadmap11 as well as known DNaseI hypersensitive locations, FAIRE-seq peaks, and CTCF binding sites from more than 100 different cell types, which were collected from the ENCODE data12.
