phenotype, and suggested that whereas the OLF domain is required for interaction with FLRTs, both the RBL and OLF domains are involved in the interaction with teneurin 1 (TEN1), a cell surface protein involved in brain development. These data indicate that the extracellular domain of LPHN3 contains a distal ligand binding module situated on an elongated and potentially flexible stalk long enough to span the synaptic cleft, with differentiable FLRT3 and TEN1 binding sites (O’Sullivan et al., 2014).
