of heterozygous (informative) sites in expressed transcripts. Nevertheless, KLF4 is a strong candidate gene. In prior studies, knockdown of KLF4 in MCF-7 cells affects proliferation, migration, and invasion (Akaogi et al., 2009; Yu et al., 2011). In addition, KLF4 has been shown to play a potent oncogenic role in mammary tumorigenesis by maintaining stem cell-like features (Yu et al., 2011). In agreement with the importance of KLF4 in driving stem cell features is the seminal observation that KLF4 is 1 of 4 TFs required for generating induced pluripotent stem cells (Takahashi et al., 2007).
