diet- or obesity-related changes in expression in hypothalamus21,29-34. Further general support for a neuronal basis for obesity comes from the observation that NEGR1 is thought to affect neuronal outgrowth24,25. Finally, the effect of variants that map to a gene desert between GNPDA2 (Supplementary Fig. 3) and GABRA2 (ref. 35) might be mediated by GABRA2, which affects addiction behavior36-38. Abundant evidence supports multiple possible roles of the CNS on body weight regulation, including on appetite, energy expenditure and other behavioral aspects39. Determining the precise mechanism of action of these loci will require further experimentation.
