The principal investigator on the Lothian Birth Cohort 1936 grant was IJD, and JMS, VW, HC, LJW, DJP and PV were co-investigators. The investigators designed the study, with IJD and JMS taking principal responsibility for compiling the psychological and medical phenotypes, respectively. MDT and IJD revised the protocol for testing subjects. AJG contributed to the LBC1936 Study Questionnaire design. MDT, AJG, JC, CB and CC collected, entered and checked the data. IJD drafted the article, with sections contributed by AG, JC and CB. All authors read and contributed to revising the article.