In summary, we have identified a strong association of OCD with a 3-marker haplotype composed of eQTLs for SLC1A1, which in turn were determined by exploiting expression and genotype data repositories and further validated with brain expression studies and reporter assays. Our complementary expression analysis approach might prove to be of use in future genetic studies for genes expressed at quantifiable levels in lymphoblastoid cell lines and other population-based tissue collections. Our haplotypic association results call for continued appreciation of glutamatergic neurotransmission abnormalities in OCD research.
