Chunk #36 — THEORETICAL DERIVATIONS — IMPACT OF LD ON DISEASE PARAMETERS — Multiplicative model

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Disease model distortion in association studies.

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Zondervan and Cardon [2004] derive a similar formula, but expressed in terms of different parameters. They parameterize LD in terms of the disequilibrium coefficient, D = Pr(11) − fAfB, instead of r, and use the OR instead of the RR (recall that we are using a log risk regression model),