In this article, we review neuroimaging intermediate phenotype findings related to schizophrenia and evidence of genes associated with increased risk for schizophrenia that modulate these intermediate phenotypes (Figure 1B 1–3). We will focus on schizophrenia and fMRI as an example, but the model can be extended to other psychiatric disorders and other neuroimaging techniques. Based on previous reviews [14–16], studies have been grouped into five different cognitive domains whose circuits have been consistently reported altered in patients with schizophrenia.
