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Chunk #10 — Materials and Methods — Genotyping and Data Analysis — Quality control (QC)

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Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
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Prior to QC, the genotype data were pooled with the preQC data from GWAS1. QC was then performed on the pooled data. The following criteria were applied: sample call rate (CR) >=0.98; and conformity between reported sex and genotypic sex. In the case of duplicates or cryptic relatedness (IBS across autosomal markers >=1.6), the sample with the lower call rate was removed. Outliers were identified using PCA.