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Chunk #28 — Materials and Methods — Gene expression dataset using Affymetrix Exon Array

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A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci.
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The mRNA expression was assayed in HapMap lymphoblastoid cell lines (LCLs) in 87 CEU and 89 YRI using the Affymetrix GeneChip Human Exon 1.0 ST Array [18]. This dataset is available in the public repository Gene Expression Omnibus (Accession No: GSE9703). Measurements on the exon array are done both at the exon-level and at the gene-level. The exon array includes 1.4 million probesets and profiles nearly 13,000 transcript clusters. The transcript clusters include a set of probesets containing all known exons and 5′ and 3′ UTR regions in the genome so that probes interrogate entire gene regions and not just 3′ UTRs (in contrast to other arrays).