With respect to categorical comparisons of MA dependent vs. non-dependent individuals (Supplementary table 2), those with MA dependence in the total sample were less likely to be married (p=0.004) and employed (p<0.001), more likely to be dependent on alcohol (p<0.001) and nicotine (p<0.001), have ASPD (p<0.001), have earlier onset of MA use (p=0.001), have longer history of MA use (p=0.001), use more MA on a daily (p<0.001) and monthly basis (p<0.001) during their period of heaviest use, as well as have more lifetime episodes of MA use (p<0.001). Likewise, being currently unmarried (p=0.039), unemployed (p=0.006), having comorbid alcohol dependence (p<0.001), nicotine dependence (p<0.001) and ASPD (p<0.001), having earlier onset of MA use (p=0.003), and having longer history of MA use (p<0.001) were associated with MA dependence in males, while alcohol (p=0.032) and nicotine dependence (p<0.001) were associated with MA dependence in female MA users. In both sexes, individuals with MA dependence were more likely to have greater daily (p<0.001) and monthly MA use (p<0.001) during the periods of their heaviest use as well as having more lifetime episodes of MA
