tissues relate to AUD remain to be discovered. By searching the drug target gene database, we found four genes (DRD2, PDE4B, GRM5, and SLC6A9) were already targets of AUD treatment drugs (Table S6). We also found 22 genes that were targets of drugs to treat other diseases (Table S6) and could be examined and/or repurposed to treat AUD. Studies have found that gene-targeted drugs were more likely to get FDA approval [24, 52, 53], therefore, identifying the roles of genes used in calculating PRSgene could facilitate the development of novel treatment methods.
