Although gene targeting approaches in animal models might ultimately be the most robust method for validating the role of individual genes in ethanol response behaviors, such studies are complex and time-consuming. We chose, as an initial approach to validate our cross-species ranking algorithm, a study of the association of the gene ranking score with alcoholism traits in a GWAS analysis. We found a reduction in the minimum FDR q-value as the ranking score increased to 2. It is important to note that this effect is not due to the progressive limiting of markers examined. In this study, FDR is not dependent on the number of tests performed.
