Chunk #51 — RESULTS — Hyperexcitability is reversed by chronic Li treatment of LR DG-like neurons but not of NR neurons, and Li treatment reduces cell capacitance in both LR and NR neurons
and LR neurons, Li generally decreases the fast AHP and broadens the spike but opens the sodium channels at a lower (less depolarized) potential. The final effect depends very much on the initial properties of the cell. For example, in the NR neurons, as the sodium channels are much less open at − 40 mV than in the LR neurons, this opening of the channels due to the Li treatment may help in the shift of many neurons to the ‘hyper’ state, whereas this effect is less strong in the LR neurons.
