were tested over a 5-hour period on separate days, whereas a cumulative dosing procedure was used by Holdstock and de Wit (2000), in which a low dose of alcohol (0.2 g/kg) was administered every 30 min for a maximal dose of 0.6 g/kg and peak breath alcohol levels were lower than 75 mg/dl. A higher dose of alcohol was used in the present study (0.75 g/kg), with correspondingly higher peak breath alcohol levels (over 90 mg/dl). Another difference is that the sample size in the Holdstock and de Wit (2000) study was substantially smaller (n=16) than the present study (n=45). Another important difference is that we specifically recruited women with a paternal history of alcoholism (n=25), whereas Holdstock and de Wit (2000) reported that only two women were FHP. As addressed in the Introduction and discussed below, the presence of a family history of alcoholism can alter the response to alcohol.
