antagonists, such as naltrexone, lessen reinforcing effects of multiple addictive substances, including from alcohol,8 opioids,9 stimulants,10,11 and sedatives,12 high treatment discontinuation rates associated with naltrexone in studies of individuals with OUD6 have raised questions about whether buprenorphine may hold similar promise in treating OUD in people with cooccurring SUD. Research examining the comparative effectiveness of buprenorphine and naltrexone in individuals with polysubstance use is thus needed.
