Moreover, in addition to bipolar disorder and ASPD, MDD and PTSD were associated with an increased likelihood of cocaine dependence treatment or self-help participation. While mood and anxiety disorders may not increase cocaine dependence severity, they may add psychosocial burden that could motivate cocaine dependent adults to seek treatment or self-help. This finding underscores the importance of targeted psychotherapy or pharmacotherapy for mood or anxiety disorders when they co-occur with cocaine dependence.