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Chunk #0 — Background

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Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations.
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Type 2 diabetes (T2D) is a common, chronic disease caused by both genetic and environmental risk factors and their interactions [1], which has significantly increased prevalence in the past 20 years [2] and disproportionately afflicts communities of color [3–5]. The current screening of T2D focuses on individuals with demographic and clinical risk factors, including overweight or obesity, age >35 years, and a family history of diabetes [6]. However, despite preventative strategies and public health efforts to improve nutrition and physical activity, facilitate access to care, and limit tobacco and alcohol use, the morbidity and mortality associated with T2D remain unaltered [5], likely because most interventions are adopted too late in the course of disease trajectory.