In an analysis restricted to children with ADHD without intellectual disability, eight of 40 CNVs larger than 500 kb identified in the ADHD group overlapped with a locus previously implicated in autism,7,26–30 compared with only one of 78 in controls (p=0·0095; table 2). No specific single autism locus showed a significant excess of CNVs in children with ADHD (table 2). We also found that of the CNVs identified in ADHD, nine of 40 overlapped with a locus previously implicated in schizophrenia (p=0·010).9,10,22,31 Locus-specific tests revealed that this finding was largely due to the 16p13.11 region (p=0·0012), where we identified six duplications in participants with ADHD (table 2; figure 1 and figure 2). Logistic regression analysis showed no significant association between CNV size and overlap with autism (two-sided p=0·41) or schizophrenia loci (p=0·90).
