With high lipid solubility, MA can easily pass though the blood-brain barrier. In the central nervous system, MA is the indirect receptor agonist of dopamine, norepinephrine and serotonin, promoting the release of these monoamine neurotransmitters in a variety of ways.[3,4] These neurotransmitters have physiological and psychological effects, such as euphoria, the increase of alertness, vigor and attention, and the decrease of fatigue. However, MA also leads to cardiac acceleration and hypertension.[3,4]
