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Chunk #17 — MATERIALS AND METHODS — Analytic plan

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Association of parental divorce, discord, and polygenic risk with children's alcohol initiation and lifetime risk for alcohol use disorder.
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We conducted analyses in two stages. We first examined the main effects of parental divorce/parental relationship discord, offspring PRSALC for the time-to-initiation of regular drinking and likelihood of lifetime AUD. Age and parental relationship discord were mean centered. The alcohol problems PRS and 10 PCs were standardized to have a mean of 0 and standard deviation of 1.