binding via the MR may impact HPA drive via synaptic mechanisms (Pasricha et al., 2010). The eventual shut-off of the HPA axis stress response (return to baseline) is thought to be mediated by feedback working through limbic circuitry (Jacobson and Sapolsky, 1991; Sapolsky et al., 1991; Boyle et al., 2005; Furay et al., 2008). Shut-off occurs in the time realm of genomic actions, and may reflect cellular changes in pathways impinging on the PVN. However, it remains possible that delayed shut-off may be mediated at least in part by non-genomic signaling.
