In examining the three groups of stress studies separately, we found strong evidence for an association between the s allele and increased stress sensitivity in studies of childhood maltreatment (p=0.00007), in studies of specific medical conditions (p=0.0004), but only marginal evidence in the studies of stressful life events (p=0.033) (Table 2, 3 and 4 respectively). The removal of individual studies did not lead to changes in the significance of the outcome in studies of childhood maltreatment (7.4E-6<p<0.00014) or specific medical conditions (0.00017<p<0.0068). However, because the genetic effect in the set of stressful life events was barely below the significance threshold (p=0.033), the result was no longer significant after the exclusion of any one of several studies 1, 32, 35, 37, 68 (0.013<p<0.62).
