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Chunk #8 — RESULTS — Associated SNPs more than 1 Mb away can be in substantial LD

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Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits.
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with a trait and that the stepwise conditional analysis is a more general approach to refine association signals and to identify additional associated SNPs. Given either of these SNPs in the model, the other SNP is not found to reach genome-wide significance with PJ > 0.001 (Table 3). In our conditional and joint analysis, only the rs1814175 SNP was selected, and no additional signals were detected in this region.