We genotyped 35 SNPs in a total of 45,018 individuals of European ancestry from nine study cohorts using Sequenom iPLEX or TaqMan (Supplementary Note). Individuals were eliminated from analysis if <80% of SNPs were called successfully. Among successfully typed individuals, genotype frequencies were in Hardy-Weinberg equilibrium (P > 10−6), call rates were >94%, and concordance of duplicate genotypes was >99% in each of the follow-up study cohorts.
