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Chunk #37 — 4. Discussion

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Differential effects of ethanol in the nucleus accumbens shell of alcohol-preferring (P), alcohol-non-preferring (NP) and Wistar rats: a proteomics study.
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The more widespread effects of repeated ethanol treatments on changes in protein expression levels in the NP than P rat, as exemplified by the greater number of proteins that were altered (Tables 2 and 3), are in agreement with the behavioral effects of repeated i.p. injections of 1 g/kg ethanol on performance on the oscillating bar task of P and NP rats, in which repeated injections produced significant changes in performance in the NP rats, but had little apparent effect on performance in the P rat (Bell et al., 2001).