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Chunk #23 — Materials and methods — Statistical analyses — PCC–HC connectivity and episodic memory capacity

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Linking DMN connectivity to episodic memory capacity: what can we learn from patients with medial temporal lobe damage?
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In a previous study, we found that stronger PCC–HC connectivity in the ipsilateral hemisphere was associated with better material-specific episodic memory capacity in patients with mTLE (McCormick et al., 2013a). In that study, we focused on the Warrington Words Recognition Test as a measure of verbal memory capacity in patients with L-mTLE and Warrington Faces Recognition Test as a measure of visuospatial memory capacity in patients with R-mTLE. In the current study, we aimed to examine whether these results would still hold true in the current, larger dataset and with our refined composite memory scores. A detailed description of the method used can be found elsewhere (McCormick et al., 2013a). In short, bilateral PCC-to-voxel connectivity maps for each individual were imported from conn into SPM8. For each patient group separately, a voxelwise one-sample t-test was conducted with one behavioural measure (e.g., verbal memory capacity) as a covariate of interest. An anatomical mask of both hippocampi were applied to the resulting images and thresholded at p < 0.05 small volume corrected (svc), cluster size > 10 voxels. This analysis indicates voxels