SG differences in brain morphometry that emerge in adolescent alcohol use may continue into adulthood, with increased vulnerability to disruptions in brain volume and cortical thickness as individuals progress toward AUD (Peltier et al., 2019). This section will highlight what is known about perturbations in alcohol-related brain morphometry in adulthood; although there are relatively few studies that examine SG differences in alcohol-related alterations in brain structure in adults and those studies that do examine SG differences demonstrate mixed results.