Anecdotally, one can predict gene function for poorly characterized genes by examining the GO enrichment of its related genes (7). For example, GRN is a gene without an annotated sub-cellular localization that was assigned a ‘lysosome’ localization in a recent article (14). The default search for GeneMANIA for GRN shows ‘lysosomal lumen’ and ‘lysosome’ (Figure 1).
