Chunk #19 — RESULTS — Damaging de novo SNVs and indels contribute to OCD risk in 22% of cases

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De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.

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We also used our data to estimate the proportion of cases harboring a de novo mutation contributing to OCD risk. By subtracting the percentage of controls from the percentage of OCD probands with at least one de novo mutation, we estimate that 15.0% (CI 3.1–26.9%) have a de novo Mis-D mutation and 7.3% (CI 0.50–14.0%) have a de novo LGD mutation mediating OCD risk. As a group, we estimate that 22.2% (CI 8.7–35.8%) of cases have a damaging de novo mutation contributing to OCD risk (Figure 2B).