most genotyping chips because of their relatively low frequency in European populations (MAF=3%). There may be other rare and novel variants like this that influence maxdrinks, which are not tagged by common SNPs and are difficult to impute. To identify these variants, whole genome, exome or targeted sequencing in large numbers of people will be needed. Further biological affirmation and replication in independent datasets will be required to confirm the role of the genes identified in this study in alcohol consumption traits such as maxdrinks.
