In MDD, much of the evidence suggests harmful consequences of cannabis use. In a 40-year study that analyzed a cohort of over 400 individuals across several time points, cannabis use was correlated with an increased risk of receiving a MDD diagnosis, and earlier onset of cannabis use was correlated with a shorter time to MDD presentation [129]. Other studies have shown similar results, demonstrating a positive correlation between cannabis use and depression, of which chronic use further strengthens this association [75, 120]. One study found the association between MDD and cannabis only in those with CUD, rather than those who occasionally use cannabis, while other studies describe weekly cannabis use being sufficient [4, 75]. This warrants a deeper investigation towards the extent of cannabis use (e.g. frequency and CBD/THC potency) that is necessary to better understand this association. Not only has cannabis use been shown to potentially predict risk of developing MDD, but it has also been shown to promote depressive symptom progression [5, 106]. Despite a substantial collection for the harmful implications of cannabis on depressive outcomes, there are
