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Chunk #16 — Materials and Methods — Genotyping and Imputation

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Genome-wide association uncovers shared genetic effects among personality traits and mood states.
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Due to differences in SNP arrays used between cohorts, genomic coverage was extended to ~2.5M common SNPs by imputation using the HapMap phase II CEU data (NCBI build 36 (UCSC hg18)) as the reference sample and MACH software. SNPs with low imputation quality (r-squared<0.30) were removed.