The lateral ventricles are distinctive as a brain morphometry measure, as they are compartments filled with cerebrospinal fluid, rather than gray or white matter structures. Lateral ventricle size measures are usually interpreted as an indirect assessment of loss of the tissue from the neighboring structures that define its borders. The increasing size of lateral ventricle volume is shown in Fig. 2d. That ventricular volume increases so robustly during typical child and adolescent development should be considered when interpreting the many reports of increased ventricular volumes in a broad range of neuropsychiatric conditions.